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Grass-Fed, Pasture Rasied, 20% IgG+

Colostrum+ Gut

Colostrum+ Gut

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Rated 4.9 out of 5 stars
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Containing an estimated 250+ Bioactives, Colostrum is one of the most scientifically researched supplements for gut health. Also called liquid gold, Colostrum gets to the root cause of gut issues by nourishing the gut microbiome, repairing leaky gut and boosting the immune system at the gut level.

✔️ Immunoglobulins (IgG, IgM, IgA).
✔️ Secretary Immunoglobulin (SIgA).
✔️ Growth Factors (IGF-1 & 2, TGF-β1 & β2).
✔️ Epithelial Growth Factor (EGF).
✔️ Prebiotic Oligosaccharides.
✔️ Anti-Inflammatory Cytokines.
✔️ Proline Rich Polypeptides.

✔️ Lactoferrin & so much more.

Scientific Studies Show That Colostrum:

🌟 Is 3x More Effective than the Flu Vaccine.
🌟 Repairs Leaky Gut Syndrome.
🌟 Reduces Diarrhoea by 70%
🌟 Increases Beneficial Gut Bacteria.
🌟 Decreases Pathogenic Gut Bacteria.
🌟 Reduces Intestinal Inflammation.
🌟 Helps Clear Gut Endotoxin.
🌟 Promotes Skin & Collagen Production.
🌟 Speeds Up Wound Healing.
🌟 Reduces Allergies & Congestion.
🌟 Protects Against URTIs.
🌟 Reduces Respiratory Illness Symptoms.

The Gold Standard In Colostrum:

Our colostrum is the only colostrum sourced from a unique set of pastures located near New Zealand's Southern Alps. Sourced from grass-fed and pasture raised cattle only, we use low thermal processing to maintain colostrums impressive bioactive profile when turning it into a bioavailable powder.

✔️ Verified & Tested 20% IgG+, IgM & IgA.
✔️ Verified & Tested IGF-1 & 2, TGF-β1 & β2.
✔️ Verified & Tested Vitamin & Minerals.
✔️ Proprietary Low Thermal Processing.
✔️ Optimal Powdered Form.
✔️ Responsibly Collected At All Times.
✔️ Collected Only During Calving Season.
✔️ No Antibiotics or Hormones.
✔️ No Additives, Preservatives or Fillers.
✔️ Halal & Kosher.

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Colostrum Is #1 For Overcoming Stubborn Gut Issues

Containing 250+ bioactives, colostrum is a scarce superfood shown to get to the root cause of gut issues including IBS, chronic bloating, excessive gas, irregular bowel movements, sugar cravings + much more.

  • 179+ Studies

  • 250+ Bio Actives

  • 20% Active IgG+

  • Growth Factors+

  • Southern Alps+

  • Gut Repair+

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A Leaky Gut Barrier Causes Gut Issues. Colostrum Helps Repair This Barrier.

  • The Importance of A Healthy Gut Barrier

    The gut plays a critical role in optimal health. When the gut lining is healthy, it is a barrier of tight junctions. These junctions selectively absorb nutrients, vitamins, minerals and amino acids while keeping out allergens, bad bacteria, toxins, gliadin and viruses. However, certain lifestyle factors can damage this barrier leading to a host of downstream effects. Thousands of studies now demonstrate that the gut barrier holds the delicate balance between health and disease.

  • Lifestyle Factors Damage the Gut Barrier Leading to Chronic Gut Issues

    Processed foods, pesticides, sugar, alcohol, antibiotics and chronic stress damage our gut barrier, leading to leaky gut syndrome (intestinal hyper permeability). When our gut junctions become leaky, bad bacteria, allergens and toxins can leak into the blood stream resulting in immune activation and inflammation. With time, this ongoing reaction can give rise to inflammatory conditions such as IBD or more commonly, symptoms that resemble those experienced in IBS. Gas, bloating, constipation, diarrhoea, stomach cramps can all be tied back to a disrupted gut barrier. Leaky gut is the true cause of IBS.

  • Colostrum Contains the Essential Building Blocks Required to Repair An Unhealthy Gut Barrier.

    Colostrum contains an estimated 250+ bioactives, many of which have anti-inflammatory, antimicrobial, anti-pathogen, antioxidant and immunodulatory benefits at the gut level. Some of these bioactives include Immunoglobulins, sIgA, Growth Factors, Lactoferrin, Oligosaccharides, Prebiotics, Cytokines, Proline Rich Polypeptides + much more. Colostrum also contains a host of essential vitamins and minerals which are foundational to gut health.

  • The Science Speaks For Itself, Colostrum Repairs The Gut Barrier Fast (Bye Bye IBS)

    Multiple studies demonstrate that bovine colostrum can help reverse leaky gut. For example, just 500mg (small dose) of colostrum was shown to improve leaky gut (1). While two other studies found that colostrum improved and blunted leaky gut by 70% and 80% respectively (2)(3). We also have studies showing that colostrum led to a significant reduction in Zonulin levels, the main test for measuring intestinal permeability (4).

In Addition to Repairing Leaky Gut, Studies Show Colostrum Benefits Multiple Areas of Gut Health.

  • Reduced Diarrhea By 70%

    Overcome loose stools and recover quicker from illness. In a meta-analysis looking at 5 double blind placebo controlled studies, bovine colostrum was shown to reduce the occurrence of diarrhoea by 70% (5). Colostrum reduced stool frequency and pathogen detection in stools.

  • Boosts The Growth of Good Bacteria

    Those with IBS often have low levels of beneficial bacteria. In studies, colostrum has been shown to increase Bifidobacterium spp, Lactobacillus spp, short-chain fatty acid microorganisms and also improve the diversity and abundance of good bacteria (6)(7)(8).

  • Increased SIgA by 79%

    sIgA is an immunoglobulin which protects our immune barriers, including the gut. Low SIgA levels are linked with food sensitivities, allergies, IBD and IBS symptoms. In one study, bovine colostrum was shown to increase s-IgA levels by 79% after 12 weeks of supplementation (9).

  • Combats Bad Bacteria & Gut Pathogens

    Gut pathogens and bad bacteria are often the main culprits behind bloating, gas and loose stools. In studies, colostrum has been shown to shift dysbiotic (unhealthy) gut environments towards eubiotic (good) gut environments (10). Studies also showed that colostrum reduced levels of e.coli, worked against H.Pylori and cleared C.difficile when paired with a probiotic (11)(12)(13).

  • Reduced Gut Endotoxin (LPS) by 67%

    People with IBS have elevated levels of Endotoxin, which as a metabolite produced by negative gram bacteria in the gut. It has also been connected with weight gain, inflammation and is one of the leading causes of inflammatory conditions. In multiple studies, colostrum has been shown to reduce plasma endotoxin (14)(15)(16). In one study, it reduced it by as much as 67% (17).

  • Helps Repair The Intestinal Villi

    IBS sufferers often have irregular and damaged intestinal villi. These villi make up the tight junctions in the gut but can easily be damaged by lifestyle factors, coeliac disease and certain medications. In studies, colostrum was shown to help repair the intestinal villi aswell as repair gut damage caused by medications like NSAIDs by 30-60% (18)(19).

    A Closer Look At Colostrums Bioactives Benefits

    Immunoglobulins

    Colostrum is the richest source of Immunoglobulins, containing 100x more immunoglobulins compared to mature milk.

    At the gut level, Immunoglobulins act as a defence system against bacteria, toxins, viruses, and other antigens. They bind, recognise and destroy these toxins thereby fortifying the gut barrier and regulating the innate and adaptive immune system.

    Secretory IgA

    Secretory IgA is one of the most important immune molecules which plays an essential role in ensuring the health of the gut barrier. It prevents the overgrowth of mucosal pathogens and bad bacteria.

    Low SIgA levels have been found in people with IBD, IBS, food Intolerances, intestinal permeability and autoimmunity.

    Colostrum has been found to help increase and modulate IgA levels. In one study, long distance runners taking bovine colostrum for 12 weeks, improved s-IgA levels by 79%.

    Growth Factors

    Colostrum contains close to 50 different growth factors including IGF-1, IGF-2, TGF-β and TGF-α which are exclusive to bovine colostrum.

    Growth factors are natural proteins which promote healing and repair. Many of these growth factors have been shown to display antihypertensive, antioxidant, antithrombotic, antimicrobial, anti-inflammatory and immunomodulatory activity.

    Studies show that growth factors repair intestinal cells, enhance immunity, build lean muscle and enhance wound repair.

    Lactoferrin

    Lactoferrin in an iron binding glycoprotein which plays an important role in iron regulation and immune health.

    Lactoferrin displays antioxidant, antimicrobial and immunomodulatory activity. It is effective against viruses, pathogens (like e.coli), the common cold and viral gastro-enteritis. It also reduces pathogenic microbial load.

    Studies show that lactoferrin is more effective at increasing iron levels than synthetic iron tablets. It has also been shown to restore the gut mucosal barrier.

    Oligosaccharides

    Bovine colostrum is a rich source of Prebiotic oligosacchardies.

    Oligosaccahrdies are the only prebiotic shown to promote the growth of Bifidobacterium. This probiotic or species of bacteria has been shown to reduce gut permeability, inflammation and restore gut homeostasis (e.g. crowding out bad bacteria in favour of the good guys).

    New evidence is also looking at the role of prebiotic oligosaccharides in obesity prevention. For example, one study showed that the consumption of oligosaccharides significantly reduced weight gain and reduced intestinal permeability.

    Proline Rich Polypeptides

    Proline Rich Polypeptides are incredibly small chains of amino acids that have powerful effects on immunity.

    They have been shown to promote T-lymphocyte function, stimulate undifferentiated lymphocytes, promote the growth of B cells, enhance natural killer cell activity, increase the proliferation of leukocytes and inhibit viruses known to be linked with autoimmune disease.

    One specific Proline rich polypeptide called colostrinin has recently been shown to improve cognition and outcomes in patients with mild to moderate dementia.

    Enzymes

    Colostrum contains about 70 different enzymes with lysozymes and nucleases being the most common.

    Lysozymes play a key role in innate immunity and provide protection against bacteria, viruses and fungi. They exert anti-microbial activity and improve gut health, metabolic markers and act as a natural antibiotic against bad bacteria.

    a-Lactalbumin

    a-Lactalbumin is a whey protein that plays an important role in maintianing muscle mass and aiding in weight loss.

    It has been shown to improve sleep, protect against gut infections and support an overall healthy microbiome.

    The Only Colostrum Sourced From Pastures Located Near New Zealands Southern Alps.

    The Gold Standard in Colostrum: The Southern Alps

    Our colostrum is sourced from a unique set of pastures located on New Zealand's South Island. These pastures are surrounded by the Southern Alps with lands so picturesque they could feature on a postcard. Cattle roam the lands freely and are grass-fed and 365 day pasture raised.

    When it comes to dairy farming, We believe New Zealand is the Gold standard. Unfortunately, only 10% of the worlds dairy cattle are grass-fed. While Australia is the best for beef producing cattle, Aus dairy cattle are often fed a bit too much grain for our liking. While in the US, almost 60% of colostrum does meet the required standards for quality.

    Low Thermal Processing, More Active IgG+ and Meticulously Tested

    Low Thermal Processing:

    Proprietary low thermal processing is used on our colostrum at temperatures much lower than industry norms. This ensures that colostrum maintains its bioactive compounds.

    20% Active IgG+

    20% IgG is the hallmark of high quality colostrum as it is the most concentrated bioactive. Our colostrum is exclusively selected from batches exceeding 20% IgG+.

    Low thermal processing maintains IgG activity. Higher temperature processing can denature IgG and impact the reliability of the commonly used affinity HPLC testing method. This means that 20% IgG may be closer to 15% if low thermal processing is not used.

    Meticulously Tested:

    We provide comprehensive testing for microbiologics, IgG, IgA and IgM. We are also one of the rare companies who test IGF-I, IGF-II, TGF-β1, TGF-β2 as-well as test for complete vitamin and mineral counts.

    Responsible Sourcing: Colostrum Is A Rare Resource

    Colostrum is a scarce resource and is only collected during the cattles natural calving season. Only surplus colostrum is collected. This ensures the calf gets all the colostrum it needs to develop and be healthy with the remainder then being collected.

    In order to meet yearly demand, colostrum is sourced from multiple different New Zealand farms across the South Island. It is then processed within 48 hours to maintain Colostrums Bioactives.

    Avoid colostrum or milk products which come from factory farmed dairy where cows may get artificially inseminated leading to inhumane collection of milk and colostrum.

    Frequently Asked Questions

    How Quickly Will I Feel The Benefits?

    As everyone is different, there is some individual difference in how quickly someone will see benefits. For some, they will experience benefits right away. For others, it might take a few weeks to a couple of months of consistent use to start to see more transformational benefits.

    In saying that, the most commonly reported benefits pretty quickly including better bowel movements, less bloating, less gas, better athletic performance and just overall feel healthier.

    What Does Colostrum Taste Like?

    Just like whey protein but better. The taste is neutral so can be added to water, smoothies, shakes or any drink with ease. Some people dry scoop it because they love it so much.

    Can I Take Colostrum with Your Beef Liver Supplements?

    Absolutely, you are pairing the No 1 most vitamin and mineral rich whole-food (beef liver) with the most bioactive rich whole-food in colostrum. Amazing to take separately but also the ultimate combination when taken together.

    Is your Colostrum From Grass-Fed & Pasture Raised Cows?

    Yes! Our colostrum powder is sourced from Grass-fed and pastured raised New Zealand dairy cows only. We source our colostrum from a unique part of New Zealand where pastures are surrounded by the Southern Alps. It is a one of kind source of Colostrum.

    Why Did You Choose New Zealand Colostrum Over US and Australian Colostrum?

    We believe New Zealand is the gold standard for dairy and colostrum. The standards are the highest, the cattle are grass-fed and pastured raised and overall the quality meets our high standards for sourcing.

    In regards to the US, one study showed that 60% of US colostrum samples were inadequate and did not meet the standards. For example, only 39% of samples met the standards for IgG count. While US colostrum is a lot cheaper, we do not want to compromise on quality.

    Australia is the gold standard when it comes to beef and meat. This is because cattle are usually organic, grass-fed and finished like our beef liver. However, in our research, dairy farming is a different process and cows in Australia seem to be fed a bit more grain than we'd like. Still a good option but we want the best.

    Do you Use Low Thermal Drying on Your Colostrum?

    Yes, our colostrum uses low thermal processing technology to ensure more active IgG. Compared to one of the main US colostrum suppliers, our colostrum contained more active IgG.

    What Serving Size is Best For Me?

    Different colostrum serving sizes have different benefits. 3g is a good place to start. Our serving size of 3g is informed by research to suit most health outcomes. Just 500mg has been shown to improve intestinal permeability while 3g has been shown in other studies to help with athletic performance, URTIs and other health concerns.

    Why Powder & Not Capsules?

    Colostrum should not be taken in capsules in our opinion. The power tastes good and has oral mucosal benefits when consumed in this way. Capsules remove this additional benefit.

    Is this Product Safe for Those with Lactose Intolerance?

    Each serve of Colostrum does contain a small amount of lactose, so would not be advisable to those with severe lactose allergy.

    However, many with a small dairy sensitivity find they don't have an issue with colostrum. This might come down to colostrum helping with their gut, which may be contributing to the dairy sensitivity in the first place.

    If you are unsure if its right for you, always contact a health care professional before taking.

    Can I Take Colostrum While Pregnant/Breastfeeding?

    We recommend consulting with your health care professional if you are unsure about taking colostrum during pregnancy or while breastfeeding.

    Is it Halal?

    Yes, it is Halal Certified.

    Is it Kosher?

    Yes, it is Kosher Certified.

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    4.9
    Rated 4.9 out of 5 stars
    Based on 56 reviews
    Total 5 star reviews: 53 Total 4 star reviews: 3 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
    100%would recommend this product
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    56 reviews
    • JS
      John S.
      Verified Buyer
      Colostrum+
      Reviewing
      Colostrum+
      I recommend this product
      Rated 5 out of 5 stars
      9 hours ago
      Quality product

      Fantastic quality, and feel great

    • AB
      ANN B.
      Verified Buyer
      Colostrum+
      Reviewing
      Colostrum+
      I recommend this product
      Rated 5 out of 5 stars
      11 hours ago
      EXCELLENT PRODUCE

      Have been taking for two weeks, feeling much better and indigestion symptoms are improving rapidly.

    • SM
      Shannon M.
      Verified Buyer
      Colostrum+
      Reviewing
      Colostrum+
      I recommend this product
      Rated 5 out of 5 stars
      Yesterday
      Great product!

      Starting feeling better within a week of taking Colostrum+. No more upset stomach or reflux and I have more energy. Will definitely keep using Colostrum+

    • CT
      Corina T.
      Verified Buyer
      Colostrum+
      Reviewing
      Colostrum+
      I recommend this product
      Rated 5 out of 5 stars
      Yesterday
      A great product

      I noticed an improvement in my digestion, energy and overall health soon after taking it. I like to eat it dry every morning on an empty stomach. I'll definitely continue to take this for at least a couple of months.

    • PL
      Polly L.
      Verified Buyer
      Colostrum+
      Reviewing
      Colostrum+
      I recommend this product
      Rated 5 out of 5 stars
      2 days ago
      Extremely happy so far!

      Great taste! Easy to take each day, and I've noticed significant changes in my bloating already after only a few short weeks. Definitely recommend this product!

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    Scientific References

    1. Hałasa M, Maciejewska D, Baśkiewicz-Hałasa M, Machaliński B, Safranow K, Stachowska E. Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes. Nutrients. 2017;9(4):370.

    Summary: With a daily dosage of only 500mg, Bovine Colostrum supplementation was found to be both safe and effective at reducing intestinal permeability in athletes.

    2. Marchbank T, Davison G, Oakes JR, et al. OC-083 Clinical trial: influence of bovine colostrum on intestinal permeability in healthy athletes after heavy exercise. Gut. 2010;59(Suppl 1):A34.2-A35.

    • Summary: Colostrum significantly reduced intestinal permeability caused by heavy exercise. Compared to placebo, it blunted intestinal permeability by 80% and reduced apoptosis by 66%.

    3. Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. Am J Clin Nutr. 2016;104(2):526-536.

    • Summary: Colostrum was shown to significantly blunt the impact of exercised induced intestinal permeability by 70% after 14 days as well as reduce apoptosis and epithelial resistance by 35-50%.

    4. Eslamian G, Ardehali SH, Baghestani AR, Vahdat Shariatpanahi Z. Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study. Nutrition. 2019;60:106-111.

    • Summary: In a study of 70 ICU patients, bovine colostrum led to significant reductions in plasma endotoxin, zonulin levels and diarrhea when compared to the control group. Researchers noted the important implications for intestinal permeability.

    Prosser C, Stelwagen K, Cummins R, Guerin P, Gill N, Milne C. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. J Appl Physiol (1985). 2004;96(2):650-654.

    • Summary: In this animal study, bovine colostrum was shown to reduce heat induced intestinal permeability with the study concluding that colostrum may be of benefit where the gut barrier is compromised.

    Marchbank T, Davison G, Oakes JR, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol. 2011;300(3):G477-G484.

    • Summary: Participants ran for 20 min on a treadmill under controlled laboratory conditions. While running caused a significant increase in gastrointestinal permeability in placebo group, this effect was almost completely blunted in those taking colostrum.

    March DS, Jones AW, Thatcher R, Davison G. The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat. Eur J Nutr. 2019;58(4):1441-1451.

    • Summary: Participants were required to exercise for 60 min in a chamber set at 30 degrees celsium with 60% humidity. This caused significant increases in iFABP but was blunted by colostrum supplementation.

    5. Li J, Xu YW, Jiang JJ, Song QK. Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea. Sci Rep. 2019;9(1):3093.

    • Summary: In this meta-analysis looking at 5 double blind placebo controlled studies, bovine colostrum was shown to reduce the occurrence of diarrhoea by 70%. Overall, colostrum was also shown to reduce stool frequency and pathogen detection.

    6. Menchetti L, Curone G, Filipescu IE, et al. The prophylactic use of bovine colostrum in a murine model of TNBS-Induced colitis. Animals. 2020;10(3):492

    Summary: Bovine colostrum was shown to increase the growth of beneficial gut bacteria such as Bifidobacterium spp. and Lactobacillus spp.

    7. Agradi S, Cremonesi P, Menchetti L, et al. Bovine Colostrum Supplementation Modulates the Intestinal Microbial Community in Rabbits. Animals (Basel). 2023;13(6):976. 

    Summary: Colostrum was found to enhance the presence of short-chain fatty acid microorganisms, which play a crucial role in maintaining gut homeostasis.

    8. Asbjornsdottir B, Miranda-Ribera A, Fiorentino M, et al. Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice. Biomedicines. 2022;11(1):91.

    Summary: In mice, consumption of bovine colostrum was shown to increase the abundance and diversity of beneficial bacterial. It also shifted dysbiotic bacteria (bad bacteria) towards eubiosis (good bacteria). 

    9. Crooks CV, Wall CR, Cross ML, Rutherfurd-Markwick KJ. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab. 2006;16(1):47-64.

    Summary: In long distance runners, bovine colostrum was shown to increase s-IgA levels by 79% after 12 weeks of supplementation. Secretory IgA is a known mucosal immune booster and protector again URTI’s.

    10.Asbjornsdottir B, Miranda-Ribera A, Fiorentino M, et al. Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice. Biomedicines. 2022;11(1):91.

    Summary: In mice, consumption of bovine colostrum was shown to increase the abundance and diversity of beneficial bacterial. It also shifted dysbiotic bacteria (bad bacteria) towards eubiosis (good bacteria). 

    Elsasser TH, Ma B, Ravel J, Kahl S, Gajer P, Cross A. Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model. Anim Microbiome. 2023;5(1):6.

    Summary: Bovine Colostrum had a beneficial impact on microbiota, particularly in promoting the presence of the bacterial types associated with eubiosis and the segmented filamentous bacteria.

    11. Champagne CP, Raymond Y, Pouliot Y, Gauthier SF, Lessard M. Effect of bovine colostrum, cheese whey, and spray-dried porcine plasma on the in vitro growth of probiotic bacteria and Escherichia coli. Can J Microbiol. 2014;60(5):287-295.

    Summary: Bovine colostrum was shown to promote the growth of probiotic bacteria while also inhibiting the growth of pathogenic bacteria such as Escherichia coli

    12. Bitzan MM, Gold BD, Philpott DJ, et al. Inhibition of Helicobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. J Infect Dis. 1998;177(4):955-961. doi:10.1086/515256

    Summary: This in vitro study showed that bovine colostrum hinders microbial adhesion to specific lipids, influencing the interaction of H. pylori and other pathogens to their target tissues.

    13.Stuppy W. Probiotics and Colostrum in the Treament of C. difficile Colitis. The American Journal of Gastroenterology. September 2006.

    Summary: After two weeks of supplementing with 250mg of  Saccharomyces boulardii and 960mg of colostrum, 85 out of 87 patients were found free of C difficile toxins A&B. The researcher suggested that this approach could be used over antibiotics.

    14. Bölke E, Jehle PM, Hausmann F, et al. Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery. Shock. 2002;17(1):9-12.

    Summary: Bovine colostrum was successfully used in a randomised pilot human study to reduce endotoxin levels generated after abdominal surgery. 

    15. Eslamian G, Ardehali SH, Baghestani AR, Vahdat Shariatpanahi Z. Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study. Nutrition. 2019;60:106-111. 

    Summary: In this study of 70 ICU patients, those taking bovine colostrum had significantly less plasma endotoxin levels compared to the control group.

    16. Seifert J, Molkewehrum M, Oesser S, Nebermann L, Schulze C. Endotoxin inactivation by enterally applied colostrum of different composition. Eur Surg Res. 2002;34(1-2):68-72.

    Summary: The oral application of lactoferrin-enriched colostrum decreased endotoxin values by more than 50% in rats.

    17. Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002;6(6):536-539.

    Summary: In this animal study, Bovine colostrum and Bovine colostrum enriched with lactoferrin were shown to reduce plasma endotoxin levels by 67% and 80% respectively.

    18. Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut. 1999;44(5):653-658.

    Summary: Bovine colostrum reduced gastrointestinal injury in rats by 30-60% after NSAID administration. Researchers found it to be an inexpensive approach for preventing and treating the harmful effects of NSAIDs on the gut and potentially had implications for other ulcerative bowel conditions.

    19. Cairangzhuoma, Yamamoto M, Muranishi H, et al. Skimmed, sterilized, and concentrated bovine late colostrum promotes both prevention and recovery from intestinal tissue damage in mice. J Dairy Sci. 2013;96(3):1347-1355.

    Summary: Following NSAID administration, bovine colostrum was found to promote growth and healing of the intestinal villi (gut wall) in mice. Researchers recommended colostrum as a potential therapeutic agent for ulcerative and inflammatory conditions of the bowel.

    Kim JW, Jeon WK, Kim EJ. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. Clin Nutr. 2005;24(5):785-793.

    Summary: Using bovine colostrum and glutamine together may effectively decrease gut damage and bacterial translocation caused by NSAIDs in rats.